Mass Spectrometer

The Mass Spectrometer must consist of three mass analyzers, the first built on quadrupole technology, the second built on linear ion trap technology, the third on Orbitrap technology. It must be capable of performing one full cycle in 500,000 resolution at m/z 200 in full scan mode. It must be capable of performing CID and HCD at any MSn stage with fragment ion detection in either Ion trap or Orbitrap and have a mass accuracy to < 3 ppm RMS, with external calibration over 24h and without any kind of mass recalibration and < 1 ppm RMS, with internal calibration. It must have an Advanced Active Beam Guide or equivalent that prevents neutrals and unwanted ions entering the quadrupole and an ion transfer tube that must be removable without breaking vacuum.