# Generation of homozygous transgenic mice from hemizygous cryopreserved embryos

> Contract award record from UK public-sector procurement sources.

## Key facts

- Public buyer: Defra Network eTendering Portal
- Contract winner: Charles River Laboratories Ltd
- Award value: £54,764
- Tender value: £37,556
- Award date: 30 September 2022
- Published: 30 September 2022
- Contract start: 1 October 2022
- Contract end: 31 July 2025
- Stage: awarded
- Procurement category: services
- Notice ID: eee883ec-e344-473f-85f5-0c47f6df4c44-576648
- OCID: ocds-b5fd17-16d561c7-213c-4907-bd1e-862d4aa24b4f

## Description

APHA require the production of a lineage of mice \(mus musculus\) which are homozygous for a bank-vole \(Myodes glareolus\) prion transgene\. Prions cause transmissible spongiform encephalopathies \(TSEs\) such as mad cow disease in cattle which is associated with variant CJD in humans\. Animal TSEs are fatal and can be zoonotic i\.e\. can transmit from animals to human\. Rodents are used for characterising these diseases and defining their zoonotic potential\. Additional information: Please note that Defra procurement uses an E-tendering system for Procurement activities\. This is currently provided by Bravo Solutions\. To access appropriate tendering and contractual documents, please access the E-Tendering portal at https://defra\.bravosolution\.co\.uk", ensuring that your registration includes "Defra"\. If you have any problems with this system, please contact Bravo on their telephone helpline number 0800 368 4850 or by emailing them at help@bravosolution\.co\.uk\.

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## Source

[View the original notice on Contracts Finder](https://www.contractsfinder.service.gov.uk/Notice/eee883ec-e344-473f-85f5-0c47f6df4c44-576648)