Mass Spectrometer

VEAT NOTICE The University has a requirement to purchase an ion mobility mass spectrometer with associated liquid chromatography system for a dedicated proteomics facility.

The University has published this VEAT notice and intends to award a contract to Bruker Ltd, following the expiry of 10 days from the date of publication of this notice.

Additional information: The works, supplies or services can be provided only by a particular economic operator for the following reason:

absence of competition for technical reasons as detailed below:

• Achieve high sensitivity and near 100% ion utilisation through the use of trapped ion mobility or other technologies

• Capable of separating chromatographically co-eluting positional isomers of peptides containing post-translational modifications by trapped ion mobility.

• Provide high MS/MS scan speeds exceeding 120 Hz, to allow for high throughput sample analyses using short chromatographic gradients whilst maintaining high peptide identification rates

• Perform real-time database searches of peptide spectra in order to deliver a complete peptide database search result by the end of the run.

• Capable of measuring and incorporating Collisional Cross Section (CCS) values into the database search algorithm to improve peptide identification rates.

• Capable of highly selective targeted assays such as Parallel Reaction Monitoring (PRM), ideally by selecting peptide targets through a combination of mass over charge and ion mobility

• Mirror new proteomic analytical hardware provided to a partner laboratory and enable method and technology transfer between the labs.