UKRI-1161 Laser Micro-dissection Inverted Imaging System

Supply of MMI Laser Microdissection Inverted Imaging System with the ability to measure the presence of the oligonucleotide-based drugs (i.e. antisense and siRNA) within the tissue and assess drug action through measurement of changes in the mRNA and protein levels of the drug target. We require a brightfield/fluorescence microscope that can be employed to view, record and quantify tissues stained by H&E, in situ hybrisation (ISH) and immunohistochemistry (IHC). We also require an attached laser that can be employed to provide tissue section down to the single cell level for the analysis of drug, mRNA and protein levels. In addition, we require a system that can be expanded in the future through the addition of a confocal microscope.