# RFQ Awarded - Preparative HPLC

> A sourced UK public sector contract award published by National Physical Laboratory.

## Key facts

- Buyer: [National Physical Laboratory](/buyers/national-physical-laboratory/contract-awards)
- Supplier: [Waters Ltd](/suppliers/waters/public-sector-contract-awards)
- Award value: £52,629
- Award date: 17 December 2020
- Published: 13 January 2021
- Contract start: 11 January 2021
- Contract end: 10 January 2022
- Stage: awarded
- Procurement category: goods
- Notice ID: eec02384-8310-475c-b473-8289a70ca29e-405387
- OCID: ocds-b5fd17-99c55ccf-4aec-4043-ab96-dd99018a8b8b

## Description

The National Physical Laboratory \(NPL\) requires automation to facilitate the purification of peptides which have been synthesized via 9-Fluorenylmethoxycarbonyl \(Fmoc\) Solid Phase Peptide Synthesis \(SPPS\)\. Due to the intrinsic nature of this synthetic technique, it is quite common to isolate crude peptides as a mixture of the desired product and closely related impurities \(e\.g\. protecting group adducts / deletion sequences\)\. NPL tends to synthesize difficult peptides \(self assembling, repeating motifs, slightly insoluble sequences\) on 0\.1 mmol scale via microwave assisted Fmoc SPPS; yielding 150 mg to 400 mg of crude product after resin cleavage\. NPL is seeking to purchase a preparative HPLC, which will facilitate the purification of larger quantities of crude peptide per run \(than we are currently able, i\.e\. >> 15-20 mg per un\); and therefore yield greater quantities of highly pure peptides\.

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## Source

[View the original notice on Contracts Finder](https://www.contractsfinder.service.gov.uk/Notice/eec02384-8310-475c-b473-8289a70ca29e-405387)