# RFQ - Preparative HPLC

> Tender notice from UK public-sector procurement sources.

## Key facts

- Public buyer: [National Physical Laboratory](/buyers/national-physical-laboratory/contract-awards)
- Published: 23 October 2020
- Planned start: 30 November 2020
- Planned end: 1 November 2021
- Stage: open_tender
- Procurement category: goods
- Notice ID: d995b521-cba1-4fe2-b58c-b74bcab1f139-389157
- OCID: ocds-b5fd17-bd69fc46-6497-4b2a-8172-a9bc30e8db8e

## Description

The National Physical Laboratory \(NPL\) requires automation to facilitate the purification of peptides which have been synthesized via 9-Fluorenylmethoxycarbonyl \(Fmoc\) Solid Phase Peptide Synthesis \(SPPS\)\. Due to the intrinsic nature of this synthetic technique, it is quite common to isolate crude peptides as a mixture of the desired product and closely related impurities \(e\.g\. protecting group adducts / deletion sequences\)\. NPL tends to synthesize difficult peptides \(self assembling, repeating motifs, slightly insoluble sequences\) on 0\.1 mmol scale via microwave assisted Fmoc SPPS; yielding 150 mg to 400 mg of crude product after resin cleavage\. NPL is seeking to purchase a preparative HPLC, which will facilitate the purification of larger quantities of crude peptide per run \(than we are currently able, i\.e\. >> 15-20 mg per un\); and therefore yield greater quantities of highly pure peptides\. Additional information: Please do not contact the person listed on this notice\. Documents can only be obtained through Bravo Solutions\.

## Related contract awards

- [Strategic Reporting](/contracts/ocds-b5fd17-cba20e46-64e6-4c85-9a06-355e1356c369): National Physical Laboratory
- [Awarded - ITT - IoT 5G devices Base Station Emulator](/contracts/ocds-b5fd17-d7a738be-ed83-4f10-9015-274de9977ad1): National Physical Laboratory
- [RFQ\_128032 - Bibliometric Assessment of the National Physical Laboratory's \(NPL\) Research Output](/contracts/ocds-b5fd17-41dc673a-dc9a-460b-9050-40d4b085cbf7): National Physical Laboratory

## Source

[View the original notice on Contracts Finder](https://www.contractsfinder.service.gov.uk/Notice/d995b521-cba1-4fe2-b58c-b74bcab1f139-389157)