# Microcirculatory changes during haemorrhagic shock in relation to shock and subsequent inflammatory responses

> A sourced UK public sector contract award published by Defence Science and Technology Laboratory.

## Key facts

- Buyer: [Defence Science and Technology Laboratory](/buyers/defence-science-and-technology-laboratory/contract-awards)
- Supplier: [King's College London](/suppliers/king-s-college-london/public-sector-contract-awards)
- Award value: £54,992
- Tender value: £54,992
- Award date: 11 October 2021
- Published: 27 October 2021
- Contract start: 12 October 2021
- Contract end: 31 August 2022
- Stage: awarded
- Procurement category: services
- Notice ID: a7226318-3f6d-4251-b405-2014f4c2cf80-480234
- OCID: ocds-b5fd17-f00d81b7-9ef7-4f8a-b794-f7bfb4e3b52d

## Description

The cardiovascular response to trauma \(tissue injury, haemorrhagic shock and resuscitation\) leads to inflammatory responses that can either cause further damage or underpin subsequent tissue healing\. A novel element of the inflammatory response is the interaction between platelets and neutrophils, which have been examined in a collaborative pilot study with King's College, who have expertise in neutrophil-platelet interactions\. The inflammatory response in trauma is in part orchestrated by the microcirculation\. There is considerable inter-individual variation in the microcirculatory response to trauma\. A detailed assessment of these responses, followed by correlation with the systemic physiological and inflammatory responses, may identify mechanisms of response and potential therapeutic directions to modify the inflammatory response and augment the potential for healing\.

## Related contract awards

- [SDA Capability Map 2026 update](/contracts/ocds-b5fd17-6f95c0d4-bef3-485a-b9c5-1dff958f5895) — Defence Science and Technology Laboratory
- [Forward Asset Service Plan \(FASP01\)](/contracts/ocds-b5fd17-99492d33-8ddb-4665-84a8-7883fb4c9293) — Defence Science and Technology Laboratory
- [Insurance Purchase](/contracts/ocds-b5fd17-f0b22c6d-a6ed-4807-b3b3-99060b648091) — Defence Science and Technology Laboratory
- [Huddle Licences](/contracts/ocds-b5fd17-3cb2b925-11cc-4b3b-a515-d8cf31985c1b) — Defence Science and Technology Laboratory
- [MSc Health and Social Care Policy \(2024-27\)](/contracts/ocds-b5fd17-a3e7c36b-871e-4a5b-a83a-406bcc3f4417) — UK Health Security Agency
- [Medicine Management: An Investigation of Fentanyl Heat Expiry Following Exposure to Extreme Temperatures on Military Deployment](/contracts/ocds-b5fd17-6bca9880-9d4b-43d7-877e-07af454be505) — MINISTRY OF DEFENCE
- [Con\_26186 - AI Catalyst Fund - AI Tools for Education - Kings College London](/contracts/ocds-b5fd17-e17d4f86-b73b-4d26-abce-3bcf8ee574ce) — Department for Education
- [CP2521-24 SME Artificial Intelligence Awareness Training](/contracts/ocds-b5fd17-e7b67cb3-66ff-4d17-9b35-8234fd2472b5) — Devon County Council
- [Taxi and MPV \(1-8 seats\) Passenger Assistant - Taxi and MPV \(1-8 seats\) Passenger Assistant](/contracts/ocds-b5fd17-c807205b-b095-4dad-80ed-5eb64a2885e7) — East Sussex County Council
- [Oracle Fusion Enterprise Software](/contracts/ocds-b5fd17-b94faf4e-06c9-470e-af64-acbf9a5af410) — DEPARTMENT OF HEALTH AND SOCIAL CARE
- [National Roads Telecommunications Service 3 \(NRTS3\) Independent Assurance Review](/contracts/ocds-b5fd17-4a336c05-e4fd-4530-86b6-b037c17f1acd) — National Highways Limited
- [Taxi and MPV \(1-8 seats\) Passenger Assistant - Taxi and MPV \(1-8 seats\) Passenger Assistant](/contracts/ocds-b5fd17-63f8a7e1-2c91-4e8e-a7e9-fb3b7b757186) — East Sussex County Council

## Source

[View the original notice on Contracts Finder](https://www.contractsfinder.service.gov.uk/Notice/a7226318-3f6d-4251-b405-2014f4c2cf80-480234)