Dianthus Nano System

Description

VEAT NOTICE The University has a requirement to purchase an instrument that features the latest innovation for characterising biomolecular binding affinities. The University has published this VEAT notice and intends to award a contract to NanoTemper Technologies GmbH following the expiry of 10 days from the date of publication of this notice. Additional information: The works, supplies or services can be provided only by a particular economic operator for the following reason: absence of competition for technical reasons Explanation: Specific features of the system include the • Measurements are performed in solution (i.e. no immobilisation is required) • Capability to quantify interactions in complex solutions (crude extract, serum) • Means to determine binding constant over a wide range (5 nM - high millimolar) as well as stoichiometry and thermodynamic parameters • Power to work at low nanomolar concentrations • Advantage of small sample volumes (20 microliter) coupled with the capacity to run samples in high-throughput mode using standard 384 well-plate • Used detection modalities based on two techniques: Spectral shift detection and Temperature-Related Intensity Change (TRIC) • Microfluidics-free • Mass independent measurement i.e., the measurable molecular weight range is from 101-107 Da • Measure up to 384 datapoints per run • Advantage of small sample volumes (20 microliter) coupled with the capacity to run samples in high-throughput mode using standard SBS 384 well-plate format

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